Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 4/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31048907 | 0.83 | SMN1; SMN2 (0.69) | ALDH1A1LMNATP53GAATHRB | |
| SCHEMBL11538033 | 0.83 | SMN1; SMN2 (0.69) | ALDH1A1LMNATP53GAATHRB | |
| SCHEMBL21629314 | 0.82 | TP53 (0.73) | PKMALDH1A1LMNATP53GAA | |
| SCHEMBL29485041 | 0.82 | ALDH1A1 (0.71) | PKMALDH1A1LMNAMAPK1NPSR1 | |
| SCHEMBL8672570 | 0.82 | ALDH1A1 (0.71) | PKMALDH1A1LMNAMAPK1NPSR1 | |
| SCHEMBL19952802 | 0.82 | PKM (0.67) | PKMALDH1A1LMNATP53GAA | |
| SCHEMBL2921293 | 0.81 | PKM (0.64) | PKMALDH1A1LMNATP53GAA | |
| SCHEMBL28942578 | 0.80 | ALDH1A1 (0.61) | PKMALDH1A1LMNATP53GAA | |
| SCHEMBL9379316 | 0.79 | PKM (0.49) | PKMALDH1A1LMNATP53GAA | |
| SCHEMBL31541287 | 0.79 | MEN1 (0.52) | PKMALDH1A1LMNAGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4014883-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-03-29 | — | — | US | disclosed |