SCHEMBL11733015

SCHEMBL11733015

O=C(O)C(O)C(O)C(O)C(O)CN[C@@H](Cc1cnc[nH]1)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.48
SLC7A5 Q01650 1/20 0.48
ITGB2 P05107 3/20 0.47
ICAM1 P05362 3/20 0.47
ITGAL P20701 3/20 0.47
ALDH1A1 P00352 3/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C19 P33261 1/20 0.46
GGT1 P19440 1/20 0.45
CA1 P00915 3/20 0.45
CA2 P00918 3/20 0.45
SLC15A2 Q16348 1/20 0.43
SLC6A5 Q9Y345 1/20 0.43
CPB2 Q96IY4 1/20 0.42
EPHX2 P34913 1/20 0.41
REN P00797 1/20 0.40
HIF1A Q16665 1/20 0.40
GABRA1 P14867 1/20 0.40
TSHR P16473 1/20 0.40
NFKB1 P19838 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11737075 0.90 CYP3A4 (0.48) CYP3A4SLC7A5ITGB2ICAM1ITGAL
SCHEMBL17861490 0.81 CYP3A4 (0.51) CYP3A4SLC7A5ITGB2ICAM1ITGAL
SCHEMBL9924208 0.80 CYP3A4 (0.53) CYP3A4SLC7A5ITGB2ICAM1ITGAL
SCHEMBL1666697 0.77 ALDH1A1 (0.58) CYP3A4SLC7A5ITGB2ICAM1ITGAL
SCHEMBL3378643 0.75 CYP3A4 (0.61) CYP3A4SLC7A5ITGB2ICAM1ITGAL
SCHEMBL11732991 0.75 PDE4A (0.34) CPB2
SCHEMBL7383006 0.75 ITGB2 (0.53) CYP3A4SLC7A5ITGB2ICAM1ITGAL
SCHEMBL11321618 0.75 CYP3A4 (0.54) CYP3A4SLC7A5ITGB2ICAM1ITGAL
SCHEMBL163397 0.74 ITGB2 (0.60) CYP3A4SLC7A5ITGB2ICAM1ITGAL
SCHEMBL17846596 0.74 CYP3A4 (0.64) CYP3A4SLC7A5ITGB2ICAM1ITGAL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4032676-A MOISTURIZERS HENKEL & CIE G.M.B.H. (DT) 1977-06-28 US disclosed