SCHEMBL11733763

SCHEMBL11733763

CC1(NC(N)=O)CCCC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HDAC3 O15379 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
DPP4 P27487 2/20 0.32
CNR2 P34972 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
PKM P14618 1/20 0.31
FFAR3 O14843 1/20 0.31
CRBN Q96SW2 1/20 0.31
KMT2A Q03164 2/20 0.31
POLB P06746 2/20 0.31
MEN1 O00255 1/20 0.31
TSHR P16473 2/20 0.30
NFKB1 P19838 2/20 0.30
CYP1A2 P05177 1/20 0.30
MAOA P21397 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11737698 0.98 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC2
SCHEMBL16323153 0.90
SCHEMBL27851275 0.78 ALDH1A1 (0.33) ALDH1A1SMN1; SMN2
SCHEMBL22310672 0.77 FFAR3 (0.38) ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC2
SCHEMBL1446029 0.77 HTT (0.38) ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC2
SCHEMBL14627310 0.75 HTT (0.41) ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC2
SCHEMBL16935128 0.75 HDAC3 (0.33) ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC2
SCHEMBL5260246 0.75 HTT (0.41) ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC2
SCHEMBL1694483 0.75 CNR2 (0.37) ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC2
SCHEMBL5219364 0.75 HTT (0.41) ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4001425-A METHODS OF TREATING HYPERTENSION AND PHARMACEUTICAL COMPOSITIONS COMPRISING 1-TERTIARY-ALKYL-3-(SUBSTITUTED FURYL)UREAS AS ANTIHYPERTENSIVE AGENTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-01-04 US disclosed
US-3969370-A 1-Tertiary-alkyl-3-(substituted furyl)ureas as antihypertensive agents E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-07-13 US disclosed