Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 15/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | DRD4 | P21917 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | HTR2C | P28335 | 6/20 | 0.47 |
| ▸ | HTR7 | P34969 | 6/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | HTR2B | P41595 | 5/20 | 0.47 |
| ▸ | HTR1D | P28221 | 5/20 | 0.47 |
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | DRD1 | P21728 | 4/20 | 0.47 |
| ▸ | DRD5 | P21918 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11738985 | 0.86 | ACHE (0.49) | OPRM1OPRL1SIGMAR1DRD2DRD1 | |
| SCHEMBL11735308 | 0.85 | OPRL1 (0.54) | OPRM1OPRL1OPRD1OPRK1BCHE | |
| SCHEMBL11739462 | 0.84 | ACHE (0.52) | SIGMAR1BCHEACHE | |
| SCHEMBL11736447 | 0.84 | ACHE (0.50) | BCHEACHE | |
| SCHEMBL11732327 | 0.84 | ACHE (0.49) | SIGMAR1DRD4HTR2BSLC6A2SLC6A3 | |
| SCHEMBL11735265 | 0.83 | SIGMAR1 (0.50) | SIGMAR1ACHE | |
| SCHEMBL11734383 | 0.82 | ACHE (0.49) | SIGMAR1DRD4HTR2BSLC6A2SLC6A3 | |
| SCHEMBL11735116 | 0.82 | ACHE (0.51) | BCHEACHE | |
| Hydrochloric Acid SCHEMBL11737929 | 0.81 | ACHE (0.48) | SIGMAR1DRD4HTR2BSLC6A2SLC6A3 | |
| SCHEMBL11729808 | 0.81 | ACHE (0.48) | SIGMAR1DRD4HTR2BSLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4016281-A | Tetralone and indanone compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-04-05 | — | — | US | claimed |
| US-4016281-A | Tetralone and indanone compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-04-05 | — | — | US | disclosed |