Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 5/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5706486 | 0.83 | MEN1 (0.44) | KCNMA1KDM4EHPGDNPC1RAB9A | |
| SCHEMBL353750 | 0.75 | KMT2A (0.36) | KDM4ENPC1RAB9A | |
| SCHEMBL352333 | 0.74 | RAB9A (0.41) | KDM4ENPC1RAB9ARXFP1 | |
| SCHEMBL115015 | 0.73 | P2RX1 (0.44) | P2RX1TMPRSS4P2RX4P2RX7STK39 | |
| SCHEMBL116427 | 0.72 | PARK7 (0.48) | P2RX1TMPRSS4P2RX4P2RX7STK39 | |
| SCHEMBL23303570 | 0.68 | P2RX1 (0.60) | P2RX1TMPRSS4P2RX4P2RX7SORT1 | |
| SCHEMBL4928355 | 0.68 | P2RX1 (0.76) | P2RX1TMPRSS4P2RX4P2RX7 | |
| SCHEMBL23303863 | 0.67 | P2RX1 (0.59) | P2RX1TMPRSS4P2RX4P2RX7SORT1 | |
| SCHEMBL422201 | 0.66 | CFTR (0.69) | KDM4EHPGDCFTR | |
| SCHEMBL9329716 | 0.65 | TRPV1 (0.61) | P2RX1TMPRSS4P2RX4P2RX7STK39 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424850-A1 | BENZAMIDE AND NAPHTHAMIDE DERIVATIVES INHIBITING NUCLEAR FACTOR- KAP PA (B) - (NF-KB) | Profectus Biosciences, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| US-20120046357-A1 | Benzamide and Napthamide Derivatives Inhibiting Nuclear Factor-Kappa (B) - (NK-kB) | PROFECTUS BIOSCIENCES, INC. (US) | 2012-02-23 | — | — | US | disclosed |
| WO-2010127058-A1 | BENZAMIDE AND NAPHTHAMIDE DERIVATIVES INHIBITING NUCLEAR FACTOR- KAP PA (B) - (NF-KB) | PROFECTUS BIOSCIENCES, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046357-A1 | Benzamide and Napthamide Derivatives Inhibiting Nuclear Factor-Kappa (B) - (NK-kB) | NFKBIA, IKBKB, NFKB1 | P2RX1 855/4885TMPRSS4 2798/4885P2RX4 1080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.