Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 3/20 | 0.64 |
| ▸ | KIF11 | P52732 | 8/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11806405 | 0.81 | KDM4E (0.50) | MPLKIF11MEN1ALDH1A1KMT2A | |
| SCHEMBL11732624 | 0.81 | PBRM1 (0.54) | MPLPBRM1ALDH1A1HPGDCDK4 | |
| SCHEMBL27568935 | 0.80 | KIF11 (0.61) | MPLKIF11CDK4CCND1CA12 | |
| SCHEMBL2933540 | 0.77 | KCNMA1 (0.67) | MPLPBRM1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL30455267 | 0.77 | PBRM1 (0.78) | MPLKIF11PBRM1 | |
| SCHEMBL143999 | 0.77 | PBRM1 (0.78) | MPLKIF11PBRM1 | |
| SCHEMBL29844370 | 0.77 | PBRM1 (0.78) | MPLKIF11PBRM1 | |
| SCHEMBL7565777 | 0.75 | PBRM1 (0.69) | PBRM1MEN1ALDH1A1CYP1A2HPGD | |
| SCHEMBL4137128 | 0.74 | KIF11 (0.56) | MPLKIF11CDK4CCND1 | |
| SCHEMBL3230702 | 0.73 | PBRM1 (0.71) | MPLPBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3956295-A | ANTIINFLAMMATORY | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-05-11 | — | — | US | claimed |
| US-4057640-A | ANTIINFLAMMATORY | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-11-08 | — | — | US | disclosed |
| US-3956295-A | ANTIINFLAMMATORY | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-05-11 | — | — | US | disclosed |