Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.50 |
| ▸ | HTR2A | P28223 | 6/20 | 0.50 |
| ▸ | HTR2C | P28335 | 6/20 | 0.50 |
| ▸ | HTR2B | P41595 | 6/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11733530 | 0.91 | SIGMAR1 (0.47) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11735770 | 0.84 | SIGMAR1 (0.47) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11731880 | 0.84 | SIGMAR1 (0.47) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11733808 | 0.82 | OPRM1 (0.52) | DRD2SIGMAR1DRD4DRD3SMN1; SMN2 | |
| SCHEMBL11736837 | 0.77 | SMN1; SMN2 (0.47) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11735201 | 0.77 | DRD2 (0.46) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11734904 | 0.76 | OPRL1 (0.42) | DRD2SIGMAR1DRD3OPRM1OPRD1 | |
| SCHEMBL11733344 | 0.75 | SIGMAR1 (0.42) | DRD2SIGMAR1DRD4DRD3OPRL1 | |
| SCHEMBL11730736 | 0.74 | SIGMAR1 (0.56) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11734231 | 0.71 | METAP1 (0.58) | DRD2SIGMAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4016281-A | Tetralone and indanone compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-04-05 | — | — | US | disclosed |