Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL11598070 | 0.95 | S1PR1 (0.35) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL31352954 | 0.78 | KDM4E (0.33) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL11514426 | 0.77 | CYP2A6 (0.35) | ALDH1A1HPGDKDM4EPOLBMAPT | |
| SCHEMBL7975202 | 0.74 | CYP2A6 (0.42) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL28574963 | 0.74 | AR (0.36) | ALDH1A1HPGDKDM4EHSD17B10TDP1 | |
| SCHEMBL31536461 | 0.74 | KDM4E (0.37) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL28566867 | 0.73 | AR (0.38) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL16122030 | 0.73 | TRPV4 (0.37) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL16122697 | 0.73 | AR (0.35) | ALDH1A1HPGDKDM4EKMT2APOLB | |
| SCHEMBL28571188 | 0.73 | PGR (0.33) | ALDH1A1HPGDKDM4EHSD17B10S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4021378-A | POLYURETHANES FROM CYCLIC NITRILE CARBONATE | ATLANTIC RICHFIELD COMPANY (US) | 1977-05-03 | — | — | US | disclosed |