Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.57 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.57 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.57 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.57 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.57 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.57 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.57 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.57 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.57 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.57 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.57 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.81 |
| ▸ | LSS | P48449 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8494655 | 0.98 | LTA4H (0.79) | LTA4HLSSHRH3CHRNB2CHRNA4 | |
| SCHEMBL1405661 | 0.98 | LTA4H (0.85) | LTA4HLSSHRH3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL10682691 | 0.96 | LTA4H (0.81) | LTA4HLSSHRH3CHRNB2CHRNA4 | |
| Bromide SCHEMBL8494658 | 0.94 | LTA4H (0.79) | LTA4HLSSHRH3CHRNB2CHRNA4 | |
| Ethylamine SCHEMBL9871196 | 0.90 | LTA4H (0.73) | LTA4HLSSHRH3CHRNB2CHRNA4 | |
| Tetradecane SCHEMBL28451741 | 0.89 | LTA4H (0.67) | LTA4HLSSHRH3KDM4ECYP2D6 | |
| SCHEMBL4632841 | 0.87 | LSS (0.79) | LTA4HLSSHRH3KDM4EKCNA3 | |
| Tetradecane SCHEMBL28897526 | 0.87 | LTA4H (0.69) | LTA4HLSSHRH3KDM4ECYP2D6 | |
| SCHEMBL22831331 | 0.86 | LSS (0.83) | LTA4HLSSHRH3KEAP1NFE2L2 | |
| SCHEMBL15509555 | 0.86 | LTA4H (0.68) | LTA4HLSSHRH3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258328-B2 | Method and intermediates for preparing 19-norsteroid compounds | AVENTIS PHARMA S.A. (FR) | 2012-09-04 | — | — | US | disclosed |
| US-20110046402-A1 | NOVEL METHOD AND INTERMEDIATES FOR PREPARING 19-NORSTEROID COMPOUNDS | AVENTIS PHARMA S.A. (FR) | 2011-02-24 | — | — | US | disclosed |
| US-20040229853-A1 | Novel method and intermediates for preparing 19-norsteroid compounds | AVENTIS PHARMA S.A. (FR) | 2004-11-18 | — | — | US | disclosed |
| US-4105566-A | FIREPROOFING, BIOCIDAL ACTIVITY, AMMONIUM POLYPHOSPHATE, ORGANO-TIN COMPOUND | ALBRIGHT & WILSON LIMITED (GB) | 1978-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229853-A1 | Novel method and intermediates for preparing 19-norsteroid compounds | CYP17A1, HSD17B7, CYP11B1 | ADRB2 267/4885CHRM2 3034/4885ADRB1 201/4885 |
| US-20110046402-A1 | NOVEL METHOD AND INTERMEDIATES FOR PREPARING 19-NORSTEROID COMPOUNDS | HSD17B7, CYP17A1, HSD17B13 | ADRB2 225/4885CHRM2 1624/4885ADRB1 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.