Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11744997 | 0.86 | NPC1 (0.49) | NPC1RAB9AGPR84PTGESMAPK14 | |
| SCHEMBL11745287 | 0.86 | NPC1 (0.49) | NPC1RAB9AGPR84PTGESMAPK14 | |
| SCHEMBL11327121 | 0.78 | PTGES (0.44) | GPR84PTGESALDH1A1MAPTKDM4E | |
| SCHEMBL11742743 | 0.78 | ALDH1A1 (0.49) | GPR84PTGESALDH1A1CYP1A2CASP1 | |
| SCHEMBL11749370 | 0.78 | SCN9A (0.41) | NPC1RAB9AGPR84PTGESMAPK14 | |
| SCHEMBL11745285 | 0.74 | NPSR1 (0.44) | GPR84PTGESMAPK14MAPTSCN9A | |
| SCHEMBL11749040 | 0.74 | PTGES (0.46) | GPR84PTGESALDH1A1CASP1CASP7 | |
| SCHEMBL11749033 | 0.74 | PTGES (0.43) | GPR84PTGESALDH1A1MAPTKDM4E | |
| SCHEMBL11750266 | 0.73 | CACNA2D1 (0.46) | ALOX5ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL11749644 | 0.73 | ALDH1A1 (0.44) | NPC1RAB9AGPR84PTGESALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4008232-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-3979516-A | Anti-inflammatory 3-amino-5,6-diaryl-1,2,4-triazines | ELI LILLY AND COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3948894-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1976-04-06 | — | — | US | disclosed |