Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11745287 | 1.00 | NPC1 (0.49) | NPC1RAB9AMAPK14ALDH1A1HSD17B10 | |
| SCHEMBL11742743 | 0.92 | ALDH1A1 (0.49) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| SCHEMBL11745048 | 0.87 | ALDH1A1 (0.55) | NPC1RAB9AALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL11747090 | 0.86 | NPC1 (0.44) | NPC1RAB9AMAPK14ALDH1A1HSD17B10 | |
| SCHEMBL11746301 | 0.83 | ALOX5 (0.47) | MAPK14ALDH1A1HSD17B10CYP1A2CASP1 | |
| SCHEMBL11749644 | 0.81 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL11750474 | 0.80 | CYP1A2 (0.44) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| SCHEMBL11744427 | 0.78 | PTGES (0.42) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| SCHEMBL11749370 | 0.78 | SCN9A (0.41) | NPC1RAB9AMAPK14ALDH1A1HSD17B10 | |
| SCHEMBL11751106 | 0.76 | TP53 (0.45) | NPC1RAB9AALDH1A1HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4008232-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-3979516-A | Anti-inflammatory 3-amino-5,6-diaryl-1,2,4-triazines | ELI LILLY AND COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3948894-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1976-04-06 | — | — | US | disclosed |