Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.56 |
| ▸ | FEN1 | P39748 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8573471 | 0.95 | ERCC5 (0.54) | ERCC5FEN1ALDH1A1TP53MAPK1 | |
| SCHEMBL1427082 | 0.89 | ERCC5 (0.59) | ERCC5FEN1ALDH1A1TP53MAPK1 | |
| SCHEMBL16372242 | 0.86 | ALDH1A1 (0.68) | ERCC5FEN1ALDH1A1MAPK1HIF1A | |
| SCHEMBL5081080 | 0.84 | ERCC5 (0.58) | ERCC5FEN1ALDH1A1TP53MAPK1 | |
| SCHEMBL31661827 | 0.84 | ERCC5 (0.58) | ERCC5FEN1ALDH1A1TP53MAPK1 | |
| SCHEMBL8574123 | 0.84 | CA1 (0.55) | ALDH1A1TP53MAPK1HIF1ALMNA | |
| SCHEMBL7806549 | 0.83 | NOS2 (0.58) | ERCC5FEN1ALDH1A1MAPK1HIF1A | |
| SCHEMBL15619155 | 0.83 | ERCC5 (0.57) | ERCC5FEN1ALDH1A1TP53MAPK1 | |
| SCHEMBL17746129 | 0.83 | ERCC5 (0.53) | ERCC5FEN1ALDH1A1TP53LMNA | |
| SCHEMBL30808872 | 0.83 | ERCC5 (0.57) | ERCC5FEN1ALDH1A1TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4060630-A | Ethylenediamine derivatives useful in treating sickle cell anemia | RICHARDSON-MERRELL INC. (US) | 1977-11-29 | — | — | US | disclosed |