Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | ROS1 | P08922 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11749591 | 0.84 | CES1 (0.40) | ALDH1A1CES1CHEK1 | |
| SCHEMBL11747497 | 0.82 | CSNK1G1 (0.42) | PDE3BPDE3AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL11555559 | 0.80 | ALDH1A1 (0.33) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL11633225 | 0.79 | CES1 (0.44) | POLBCES1CHEK1LRRK2 | |
| SCHEMBL11744621 | 0.78 | NR1H2 (0.38) | CHEK1 | |
| SCHEMBL11753077 | 0.78 | TGM2 (0.38) | CHEK1LRRK2 | |
| SCHEMBL11555338 | 0.77 | CHEK1 (0.46) | ALDH1A1SMN1; SMN2CHEK1ROS1CDK5 | |
| SCHEMBL11752652 | 0.76 | NOX1 (0.37) | CHEK1 | |
| SCHEMBL11553132 | 0.74 | CSNK1G1 (0.40) | PDE3BPDE3AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL11505769 | 0.72 | GAA (0.38) | PDE3BPDE3AALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4007272-A | Substituted benzodiazepin-10-ones in treating pain and depression | AMERICAN CYANAMID COMPANY (US) | 1977-02-08 | — | — | US | disclosed |
| US-3953430-A | ANTIDEPRESSANTS, ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1976-04-27 | — | — | US | disclosed |