SCHEMBL11748739

SCHEMBL11748739

Nc1ccc2c(c1)C(=O)c1c(O)cc(S(=O)(=O)O)cc1C2=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKLR P30613 2/20 0.52
NT5E P21589 3/20 0.50
NSD2 O96028 2/20 0.50
DUSP3 P51452 1/20 0.50
PTPN5 P54829 1/20 0.50
CASP6 P55212 1/20 0.50
PTPN11 Q06124 1/20 0.50
ALDH1A1 P00352 6/20 0.49
TSHR P16473 3/20 0.49
TDP1 Q9NUW8 3/20 0.49
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
MAPK1 P28482 2/20 0.49
TP53 P04637 1/20 0.49
CYP3A4 P08684 1/20 0.49
LCK P06239 4/20 0.46
MCL1 Q07820 2/20 0.44
BCL2 P10415 1/20 0.44
HSD17B10 Q99714 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7838319 0.86 ALDH1A1 (0.60) NT5ENSD2DUSP3PTPN5CASP6
SCHEMBL13239414 0.83 PKLR (0.73) PKLRALDH1A1TSHRTDP1SMN1; SMN2
SCHEMBL29337569 0.82 PKLR (0.56) PKLRNT5ENSD2DUSP3PTPN5
SCHEMBL27907616 0.81 LCK (0.67) NSD2ALDH1A1TSHRTDP1NPC1
SCHEMBL30614481 0.81 LCK (0.67) NSD2ALDH1A1TSHRTDP1NPC1
SCHEMBL5305726 0.78 PKLR (0.53) PKLRALDH1A1TSHRTDP1SMN1; SMN2
SCHEMBL1070369 0.76 MEN1 (0.53) PKLRNSD2CASP6ALDH1A1TDP1
SCHEMBL6659611 0.76 ALDH1A1 (0.59) NSD2ALDH1A1TSHRTDP1NPC1
SCHEMBL29337452 0.75 MAOA (0.63) PKLRALDH1A1TSHRTDP1SMN1; SMN2
SCHEMBL21635983 0.75 ALDH1A1 (0.65) NSD2ALDH1A1TSHRTDP1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4065446-A Reactive dyestuffs containing urea alkylene linkage between chromophore and reactive radical BAYER AKTIENGESELLSCHAFT (DT) 1977-12-27 US disclosed