Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | ADK | P55263 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11750494 | 0.87 | RXRA (0.45) | RXRARXRBRXRGNR4A2ADK | |
| SCHEMBL11754011 | 0.85 | APP (0.40) | RXRARXRBRXRGADKGPBAR1 | |
| SCHEMBL11755414 | 0.85 | APP (0.40) | RXRARXRBRXRGADKGPBAR1 | |
| SCHEMBL11755155 | 0.85 | RXRA (0.56) | RXRARXRBRXRGNR4A2NPC1 | |
| SCHEMBL11754925 | 0.85 | RXRA (0.49) | RXRARXRBRXRGNR4A2NPC1 | |
| SCHEMBL11752319 | 0.84 | NOX1 (0.48) | RXRARXRBRXRGNR4A2ADK | |
| SCHEMBL11749619 | 0.84 | NOX1 (0.48) | RXRARXRBRXRGNR4A2ADK | |
| SCHEMBL11754470 | 0.83 | MAPK14 (0.41) | NR4A2NOX1MAPTNPC1RAB9A | |
| SCHEMBL11751845 | 0.82 | RXRA (0.44) | RXRARXRBRXRGNR4A2MAPT | |
| SCHEMBL11745189 | 0.79 | RXRA (0.56) | RXRARXRBRXRGNR4A2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4051250-A | OXAZOLE, THIAZOLE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-27 | — | — | US | disclosed |
| US-3933840-A | ANTIPHLOGISTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1976-01-20 | — | — | US | disclosed |