SCHEMBL11754692

SCHEMBL11754692

Clc1nc(-c2ccc(Br)cc2)c(-c2ccccc2)s1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
MAPT P10636 3/20 0.50
CYP1A2 P05177 2/20 0.50
CYP2D6 P10635 2/20 0.50
CYP2C19 P33261 2/20 0.50
XIAP P98170 1/20 0.49
GAA P10253 3/20 0.49
KDM4E B2RXH2 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
MAPK1 P28482 2/20 0.45
PTGS2 P35354 5/20 0.45
MAPK13 O15264 1/20 0.44
GCGR P47871 1/20 0.44
MAPK12 P53778 1/20 0.44
MAPK11 Q15759 1/20 0.44
MAPK14 Q16539 1/20 0.44
NR1H4 Q96RI1 1/20 0.44
ADORA2A P29274 1/20 0.42
ADORA1 P30542 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11754207 1.00 ALDH1A1 (0.50) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL11753179 0.89 ALDH1A1 (0.60) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL11756109 0.88 NPSR1 (0.46) ALDH1A1MAPTCYP1A2CYP2C19XIAP
SCHEMBL11755758 0.88 NPSR1 (0.46) ALDH1A1MAPTCYP1A2CYP2C19XIAP
SCHEMBL11755296 0.86 KDM4E (0.55) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL11752931 0.86 KDM4E (0.55) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL11747471 0.85 MAPT (0.54) ALDH1A1MAPTXIAPGAAKDM4E
SCHEMBL11753987 0.85 MAPT (0.54) ALDH1A1MAPTXIAPGAAKDM4E
SCHEMBL11758721 0.84 SMN1; SMN2 (0.45) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL11753711 0.84 RORB (0.47) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4051250-A OXAZOLE, THIAZOLE MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1977-09-27 US disclosed
US-3933840-A ANTIPHLOGISTIC MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-01-20 US disclosed