SCHEMBL11755296

SCHEMBL11755296

Clc1ccc(-c2sc(Cl)nc2-c2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.55
GAA P10253 2/20 0.55
LMNA P02545 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
ALDH1A1 P00352 5/20 0.53
CYP1A2 P05177 4/20 0.53
CYP2C19 P33261 3/20 0.53
CYP2D6 P10635 2/20 0.53
MAPT P10636 2/20 0.53
CYP2C9 P11712 2/20 0.51
CYP3A4 P08684 1/20 0.51
PTGS2 P35354 5/20 0.46
PTGS1 P23219 4/20 0.46
PTGDR2 Q9Y5Y4 2/20 0.46
HPGD P15428 1/20 0.46
ACHE P22303 1/20 0.45
KDM1A O60341 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
NPSR1 Q6W5P4 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11752931 1.00 KDM4E (0.55) KDM4EGAALMNAL3MBTL1ALDH1A1
SCHEMBL11753179 0.93 ALDH1A1 (0.60) KDM4EGAALMNAALDH1A1CYP1A2
SCHEMBL11754948 0.93 PTGS2 (0.50) KDM4EGAALMNAL3MBTL1ALDH1A1
SCHEMBL11756117 0.86 ALDH1A1 (0.50) KDM4EGAALMNAL3MBTL1ALDH1A1
SCHEMBL11756042 0.86 MAPT (0.56) KDM4EGAALMNAL3MBTL1ALDH1A1
SCHEMBL11756348 0.86 MEN1 (0.51) KDM4EGAALMNAALDH1A1CYP1A2
SCHEMBL11754692 0.86 ALDH1A1 (0.50) KDM4EGAAALDH1A1CYP1A2CYP2C19
SCHEMBL11752472 0.86 ALDH1A1 (0.71) KDM4EGAALMNAALDH1A1CYP1A2
SCHEMBL11751348 0.86 PTGS2 (0.53) KDM4EGAALMNAALDH1A1CYP1A2
SCHEMBL11749485 0.86 MEN1 (0.51) KDM4EGAALMNAALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4051250-A OXAZOLE, THIAZOLE MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1977-09-27 US disclosed
US-3933840-A ANTIPHLOGISTIC MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-01-20 US disclosed