Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.60 |
| ▸ | AR | P10275 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11754705 | 1.00 | PGR (0.60) | PGRNR3C1CYP3A4HIF1AAR | |
| SCHEMBL11753906 | 0.93 | PGR (0.60) | PGRNR3C1CYP3A4HIF1AAR | |
| SCHEMBL11753902 | 0.93 | PGR (0.60) | PGRNR3C1CYP3A4HIF1AAR | |
| SCHEMBL11400580 | 0.93 | HIF1A (0.71) | PGRNR3C1CYP3A4HIF1AAR | |
| SCHEMBL11719344 | 0.93 | HIF1A (0.71) | PGRNR3C1CYP3A4HIF1AAR | |
| SCHEMBL11719352 | 0.93 | HIF1A (0.71) | PGRNR3C1CYP3A4HIF1AAR | |
| Water SCHEMBL11718705 | 0.92 | HIF1A (0.70) | PGRNR3C1CYP3A4HIF1AAR | |
| Water SCHEMBL11718712 | 0.92 | HIF1A (0.70) | PGRNR3C1CYP3A4HIF1AAR | |
| SCHEMBL10889875 | 0.86 | NR3C1 (0.52) | PGRNR3C1CYP3A4HIF1AAR | |
| SCHEMBL10889883 | 0.86 | NR3C1 (0.52) | PGRNR3C1CYP3A4HIF1AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4021459-A | Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy 20-keto-pregnenes | SCHERING CORPORATION (US) | 1977-05-03 | — | — | US | disclosed |