Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 2/20 | 0.55 |
| ▸ | MMP13 | P45452 | 14/20 | 0.53 |
| ▸ | MMP2 | P08253 | 12/20 | 0.49 |
| ▸ | MMP3 | P08254 | 12/20 | 0.49 |
| ▸ | MMP1 | P03956 | 11/20 | 0.49 |
| ▸ | MMP7 | P09237 | 8/20 | 0.49 |
| ▸ | MMP9 | P14780 | 6/20 | 0.48 |
| ▸ | MMP8 | P22894 | 4/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12884815 | 1.00 | HPN (0.55) | HPNMMP13MMP2MMP3MMP1 | |
| SCHEMBL1175732 | 1.00 | HPN (0.55) | HPNMMP13MMP2MMP3MMP1 | |
| SCHEMBL8004632 | 1.00 | HPN (0.55) | HPNMMP13MMP2MMP3MMP1 | |
| SCHEMBL1176564 | 0.93 | MMP13 (0.53) | HPNMMP13MMP2MMP3MMP1 | |
| SCHEMBL1176567 | 0.93 | MMP13 (0.53) | HPNMMP13MMP2MMP3MMP1 | |
| SCHEMBL12871240 | 0.86 | HPN (0.52) | HPNMMP13MMP2MMP3MMP1 | |
| SCHEMBL15705592 | 0.86 | HPN (0.52) | HPNMMP13MMP2MMP3MMP1 | |
| SCHEMBL15711183 | 0.86 | HPN (0.52) | HPNMMP13MMP2MMP3MMP1 | |
| SCHEMBL12871274 | 0.86 | HPN (0.52) | HPNMMP13MMP2MMP3MMP1 | |
| SCHEMBL15705595 | 0.86 | HPN (0.52) | HPNMMP13MMP2MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359317-B2 | Small molecule inhibitors of HIV proteases | PURDUE RESEARCH FOUNDATION (US) | 2016-06-07 | — | — | US | disclosed |
| US-20140135321-A1 | SMALL MOLECULE INHIBITORS OF HIV PROTEASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-05-15 | — | — | US | disclosed |
| US-20110046199-A1 | SMALL MOLECULE INHIBITORS OF HIV PROTEASES | PURDUE RESEARCH FOUNDATION (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046199-A1 | SMALL MOLECULE INHIBITORS OF HIV PROTEASES | SERPINB1, PRSS1, TMPRSS15 | HPN 12/4885MMP13 115/4885MMP2 57/4885 |
| US-20140135321-A1 | SMALL MOLECULE INHIBITORS OF HIV PROTEASES | SERPINB1, PRSS1, TMPRSS15 | HPN 12/4885MMP13 115/4885MMP2 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.