SCHEMBL11761663

SCHEMBL11761663

O=C=Nc1cccc(C(Cl)c2ccccc2)c1N=C=O

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.41
GABRA1 P14867 1/20 0.35
GABRB2 P47870 1/20 0.35
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28036817 0.84 CYP3A4 (0.43) CYP3A4GABRA1GABRB2
SCHEMBL11765644 0.82 GABRA1 (0.35) GABRA1GABRB2
SCHEMBL11765554 0.80 CYP3A4 (0.40) CYP3A4GABRA1GABRB2
SCHEMBL112144 0.75 CYP3A4 (0.52) CYP3A4GABRA1GABRB2TSHR
SCHEMBL28023319 0.74 GABRA1 (0.49) CYP3A4GABRA1GABRB2TSHR
SCHEMBL109280 0.73 CYP3A4 (0.62) CYP3A4GABRA1GABRB2TSHR
SCHEMBL300705 0.73 CYP3A4 (0.44) CYP3A4
SCHEMBL11881730 0.73 CYP3A4 (0.42) CYP3A4GABRA1GABRB2
SCHEMBL11342431 0.72 CYP3A4 (0.47) CYP3A4GABRA1GABRB2TSHR
SCHEMBL31119385 0.72 CYP3A4 (0.47) CYP3A4GABRA1GABRB2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4035318-A BISDIISOCYANATOBENZYLCHLOROBENZENE OLIN CORPORATION (US) 1977-07-12 US claimed
US-4035318-A BISDIISOCYANATOBENZYLCHLOROBENZENE OLIN CORPORATION (US) 1977-07-12 US disclosed
US-3952043-A CROSSLINKING AGENTS FOR POLYURETHANES OLIN CORPORATION (US) 1976-04-20 US disclosed