SCHEMBL1176396

SCHEMBL1176396

CC(=O)Nc1ccc(NC=O)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.61
HTT P42858 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
KMT2A Q03164 7/20 0.59
MAPT P10636 4/20 0.59
MEN1 O00255 4/20 0.59
ALDH1A1 P00352 3/20 0.59
TDP1 Q9NUW8 2/20 0.59
CA12 O43570 1/20 0.59
BRD4 O60885 1/20 0.59
NR1I2 O75469 1/20 0.59
CA1 P00915 1/20 0.59
CA2 P00918 1/20 0.59
MB P02144 1/20 0.59
CYP1A1 P04798 1/20 0.59
CA3 P07451 1/20 0.59
CYP3A4 P08684 1/20 0.59
RARG P13631 1/20 0.59
TSHR P16473 1/20 0.59
ALOX5AP P20292 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13703841 0.94 SMN1; SMN2 (0.73) SMN1; SMN2HTTL3MBTL1KMT2AMAPT
SCHEMBL19145203 0.89 KMT2A (0.50) SMN1; SMN2HTTL3MBTL1KMT2AMAPT
SCHEMBL17489435 0.89 TSHR (0.63) SMN1; SMN2HTTL3MBTL1KMT2AMAPT
SCHEMBL18823474 0.85 ALDH1A1 (0.65) SMN1; SMN2HTTKMT2AMAPTMEN1
SCHEMBL861674 0.83 SMN1; SMN2 (0.84) SMN1; SMN2HTTL3MBTL1KMT2AMAPT
SCHEMBL10134023 0.80 ALDH1A1 (0.59) SMN1; SMN2L3MBTL1KMT2AMAPTMEN1
SCHEMBL12175383 0.80 ALDH1A1 (0.56) SMN1; SMN2L3MBTL1KMT2AMAPTALDH1A1
SCHEMBL14861049 0.79 SMN1; SMN2 (0.62) SMN1; SMN2KMT2AMAPTMEN1ALDH1A1
SCHEMBL9785812 0.79 SMN1; SMN2 (0.57) SMN1; SMN2HTTL3MBTL1KMT2AMAPT
SCHEMBL19593994 0.79 ALDH1A1 (0.60) SMN1; SMN2KMT2AMAPTALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024072908-A1 COMPOUNDS WITH CLEAVABLE DISULFIDE MOIETIES REINVIGORON THERATECH, INC. (US) 2024-04-04 WO disclosed
US-20230323026-A1 POLYCARBONATE RESIN COMPOSITION AND MOLDED ITEM THEREOF IDEMITSU KOSAN CO.,LTD. (JP) 2023-10-12 US disclosed
EP-2966127-A1 POLYCARBONATE RESIN COMPOSITION AND MOLDED BODY Idemitsu Kosan Co., Ltd (JP) 2016-01-13 EP disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 US disclosed
US-20110045397-A1 CHARGE CONTROL AGENT AND RELATED ART KURODA KAZUYOSHI 2011-02-24 US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 US disclosed
US-20090053641-A1 CHARGE CONTROL AGENT AND RELATED ART ORIENT CHEMICAL INDUSTRIES, LTD. (JP) 2009-02-26 US disclosed
EP-2014285-A1 NPYY5 antagonists Shionogi&Co., Ltd. (JP) 2009-01-14 EP disclosed
US-5362882-A Intermediates for dyes for polyesters, images for heat sensitive elements and electrography FUJI PHOTO FILM CO., LTD. (JP) 1994-11-08 US disclosed
US-5344933-A Pyrrole ring-or condensed pyrrole ring-containing azomethine dye FUJI PHOTO FILM CO., LTD. (JP) 1994-09-06 US disclosed
US-5262377-A Colorfastness FUJI PHOTO FILM CO., LTD. (JP) 1993-11-16 US disclosed
US-5238903-A Azo-methine dye on support FUJI PHOTO FILM CO., LTD. (JP) 1993-08-24 US disclosed
US-5227359-A Pyrazoloazole dyes FUJI PHOTO FILM CO., LTD. (JP) 1993-07-13 US disclosed
US-5210200-A Fast to heat and light FUJI PHOTO FILM CO., LTD. (JP) 1993-05-11 US disclosed
EP-0518238-A1 Pyrrolotriazole derivative FUJI PHOTO FILM CO., LTD. (JP) 1992-12-16 EP disclosed
US-5128312-A Thermal transfer dye donating material FUJI PHOTO FILM CO., LTD. (JP) 1992-07-07 US disclosed
EP-0423796-A1 Thermal transfer dye donating materials FUJI PHOTO FILM CO., LTD. (JP) 1991-04-24 EP disclosed
US-4975409-A Ketone imine dyes; colorfastness; copies FUJI PHOTO FILM CO., LTD. (JP) 1990-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090053641-A1 CHARGE CONTROL AGENT AND RELATED ART H1-4, CECR2, DOT1L SMN1; SMN2 2533/4885HTT 755/4885L3MBTL1 1185/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R SMN1; SMN2 2197/4885HTT 1904/4885L3MBTL1 2541/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R SMN1; SMN2 2251/4885HTT 2095/4885L3MBTL1 3389/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.