Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | TP53 | P04637 | 4/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.75 |
| ▸ | HTR2C | P28335 | 3/20 | 0.75 |
| ▸ | HTR1A | P08908 | 2/20 | 0.75 |
| ▸ | HTR2A | P28223 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.75 |
| ▸ | MTOR | P42345 | 2/20 | 0.75 |
| ▸ | RAB9A | P51151 | 2/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | HTR5A | P47898 | 1/20 | 0.75 |
| ▸ | HTR6 | P50406 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18310351 | 0.92 | HTR7 (0.73) | HTR7MAPTTP53CYP3A4SMN1; SMN2 | |
| SCHEMBL11876604 | 0.87 | HTR7 (0.77) | HTR7MAPTTP53CYP3A4SMN1; SMN2 | |
| SCHEMBL11880169 | 0.86 | MAPT (0.75) | HTR7MAPTTP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL7517783 | 0.86 | HTR7 (1.00) | HTR7MAPTTP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL14359602 | 0.86 | HTR7 (1.00) | HTR7MAPTTP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL113526 | 0.86 | HTR7 (1.00) | HTR7MAPTTP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL29496251 | 0.86 | HTR7 (1.00) | HTR7MAPTTP53CYP3A4SMN1; SMN2 | |
| SCHEMBL11878526 | 0.84 | HTR7 (0.72) | HTR7MAPTTP53CYP3A4SMN1; SMN2 | |
| SCHEMBL11759199 | 0.82 | DRD2 (0.61) | HTR7MAPTTP53CYP3A4SMN1; SMN2 | |
| SCHEMBL11761424 | 0.82 | HTR7 (0.50) | HTR7MAPTTP53CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4011222-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-03-08 | — | — | US | disclosed |
| US-3966737-A | NEUROLEPTIC | HOFFMANN-LA ROCHE INC. (US) | 1976-06-29 | — | — | US | disclosed |