Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL11767786 | 1.00 | ALDH1A1 (0.50) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL11230219 | 0.89 | ALDH1A1 (0.61) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL11230215 | 0.89 | ALDH1A1 (0.61) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11771736 | 0.88 | KDM4E (0.59) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11771741 | 0.88 | KDM4E (0.59) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL11236812 | 0.82 | LMNA (0.53) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL11236808 | 0.82 | LMNA (0.53) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL19449713 | 0.82 | ALDH1A1 (0.53) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL13673596 | 0.82 | ALDH1A1 (0.56) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL13673595 | 0.82 | ALDH1A1 (0.56) | ALDH1A1GAAKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3992446-A | ANTIPROTOZOAL ACTIVITY, PARTICULARLY AGAINST COCCIDIOSIS AND MALARIA | AMERICAN CYANAMID COMPANY (US) | 1976-11-16 | — | — | US | disclosed |
| US-3941825-A | ANTIPROTOZOA INTERMEDIATES | AMERICAN CYANAMID COMPANY (US) | 1976-03-02 | — | — | US | disclosed |