SCHEMBL11769686

SCHEMBL11769686

C=CCn1c(=O)[nH]c(=O)n(-c2ccc(S(=O)(=O)c3ccc(Cl)cc3)cc2)c1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.40
CYP3A4 P08684 3/20 0.40
MAPK1 P28482 1/20 0.40
HPGD P15428 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
RECQL P46063 1/20 0.37
USP2 O75604 1/20 0.37
CYP1A2 P05177 2/20 0.36
CYP2D6 P10635 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
HIF1A Q16665 1/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
NTRK1 P04629 1/20 0.35
NTRK3 Q16288 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11771158 0.85 SMN1; SMN2 (0.40) ALDH1A1CYP3A4HPGDSMN1; SMN2USP2
SCHEMBL11770893 0.85 SMN1; SMN2 (0.43) ALDH1A1CYP3A4MAPK1HPGDSMN1; SMN2
SCHEMBL11775449 0.84 MAPT (0.41) ALDH1A1CYP3A4RECQLCYP1A2CYP2D6
SCHEMBL11770892 0.81 CA9 (0.49) ALDH1A1CYP3A4MAPK1HPGDSMN1; SMN2
SCHEMBL11769444 0.78 ALDH1A1 (0.46) ALDH1A1CYP3A4MAPK1HPGDSMN1; SMN2
SCHEMBL11632467 0.77 NTRK1 (0.50) ALDH1A1CYP3A4MEN1KMT2AGAA
SCHEMBL11680403 0.74 SMN1; SMN2 (0.50) ALDH1A1CYP3A4SMN1; SMN2CYP1A2CYP2D6
SCHEMBL11771017 0.73 KMT2A (0.42) ALDH1A1SMN1; SMN2CYP1A2MEN1KMT2A
SCHEMBL11770903 0.73 SMN1; SMN2 (0.49) ALDH1A1HPGDSMN1; SMN2MEN1KMT2A
SCHEMBL11768417 0.71 MAPT (0.47) ALDH1A1CYP3A4MAPK1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3970752-A Coccidiocidal compositions utilizing 1-phenyl-substituted 1,3,5-triazine BAYER AKTIENGESELLSCHAFT (DT) 1976-07-20 US disclosed
US-3948893-A COCCIDIOSIS BAYER AKTIENGESELLSCHAFT (DT) 1976-04-06 US disclosed