Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11769217 | 0.88 | MEN1 (0.35) | OPRM1KCNH2ALDH1A1RAB9ANPC1 | |
| SCHEMBL11769649 | 0.86 | TSHR (0.38) | OPRM1ADRA2ASLC6A2SLC6A4CHRM2 | |
| SCHEMBL11774087 | 0.85 | ADRA2A (0.33) | OPRM1ADRA2ASLC6A2SLC6A4CHRM2 | |
| SCHEMBL11770645 | 0.84 | GAA (0.42) | ALDH1A1LMNAL3MBTL1GAAMAPT | |
| SCHEMBL11771361 | 0.83 | NOTUM (0.35) | OPRM1ADRA2ASLC6A2SLC6A4CHRM2 | |
| SCHEMBL11768763 | 0.83 | RAB9A (0.35) | OPRM1ADRA2ASLC6A2SLC6A4CHRM2 | |
| SCHEMBL11772461 | 0.81 | RAB9A (0.36) | OPRM1ADRA2ASLC6A2SLC6A4CHRM2 | |
| SCHEMBL11767677 | 0.81 | SLC6A2 (0.35) | OPRM1ADRA2ASLC6A2SLC6A4CHRM2 | |
| SCHEMBL11767075 | 0.81 | OPRM1 (0.32) | OPRM1ADRA2ASLC6A2SLC6A4OPRL1 | |
| SCHEMBL11767082 | 0.81 | CHRM2 (0.37) | OPRM1ADRA2ASLC6A2SLC6A4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3995052-A | Indenopyran- and indenothiopyranalkylamines III in the treatment of depression | AYERST MCKENNA AND HARRISON LTD. (CA) | 1976-11-30 | — | — | US | disclosed |