SCHEMBL11770010

SCHEMBL11770010

Cn1c(=O)[nH]c(=O)n(-c2ccc(Sc3ccc(Cl)cc3)cc2)c1=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.48
GSK3A P49840 1/20 0.43
GSK3B P49841 1/20 0.43
KMT2A Q03164 4/20 0.40
GAA P10253 2/20 0.40
PKM P14618 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
RECQL P46063 1/20 0.40
MEN1 O00255 2/20 0.39
NTRK1 P04629 2/20 0.39
NTRK3 Q16288 2/20 0.39
NTRK2 Q16620 2/20 0.39
POLB P06746 1/20 0.39
MAOA P21397 1/20 0.39
MAOB P27338 1/20 0.39
LMNA P02545 1/20 0.38
IGF1R P08069 1/20 0.38
FGFR1 P11362 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11767717 0.86 GSK3A (0.41) GSK3AGSK3BKMT2AGAAPKM
SCHEMBL11774292 0.85 KMT2A (0.42) SMN1; SMN2KMT2AGAAPKMCYP3A4
SCHEMBL11810301 0.84 SMN1; SMN2 (0.42) SMN1; SMN2KMT2AGAAPKMCYP3A4
SCHEMBL21295367 0.84 NTRK1 (0.57) SMN1; SMN2GSK3AGSK3BNTRK1NTRK3
SCHEMBL11769444 0.82 ALDH1A1 (0.46) SMN1; SMN2GSK3AGSK3BKMT2APKM
SCHEMBL11768033 0.82 NTRK1 (0.36) GSK3AGSK3BCYP2C9CYP2C19NTRK1
SCHEMBL11768443 0.81 MAOA (0.42) SMN1; SMN2KMT2AMEN1NTRK1NTRK3
SCHEMBL11770880 0.81 DAO (0.36) PKMNTRK1NTRK3NTRK2IGF1R
SCHEMBL11772842 0.81 SMN1; SMN2 (0.44) SMN1; SMN2GSK3AGSK3BKMT2AMEN1
SCHEMBL11772410 0.81 PKM (0.45) SMN1; SMN2GSK3AGSK3BKMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3970752-A Coccidiocidal compositions utilizing 1-phenyl-substituted 1,3,5-triazine BAYER AKTIENGESELLSCHAFT (DT) 1976-07-20 US disclosed
US-3948893-A COCCIDIOSIS BAYER AKTIENGESELLSCHAFT (DT) 1976-04-06 US disclosed