Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TACR2 | P21452 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11758193 | 0.91 | RXRA (0.44) | RXRAKMT2AMEN1PSEN1PSEN2 | |
| SCHEMBL11763684 | 0.87 | LCK (0.38) | RXRAKMT2AMEN1MAOBMAPT | |
| SCHEMBL11765128 | 0.84 | PPARG (0.37) | RXRAMAOBMAPTPSEN1PSEN2 | |
| SCHEMBL11763558 | 0.82 | PPARG (0.35) | RXRAKMT2AMEN1MAPTATM | |
| SCHEMBL11765291 | 0.81 | MAPT (0.39) | RXRACSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL11760500 | 0.79 | AMY1A (0.38) | RXRAKMT2AMEN1MAOBMAPT | |
| SCHEMBL11763022 | 0.79 | LCK (0.36) | RXRACSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL11763889 | 0.79 | PPARG (0.50) | RXRAKMT2AMEN1MAPTPSEN1 | |
| SCHEMBL11764175 | 0.79 | ALDH1A1 (0.38) | RXRAKMT2AMEN1MAOBMAPT | |
| SCHEMBL11765965 | 0.79 | PPARG (0.33) | RXRAMAPTPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4061771-A | Ethynylindenyl compounds and derivatives thereof used in the treatment of pain, fever and inflammation | WILLIAM H. RORER, INC. (US) | 1977-12-06 | — | — | US | disclosed |
| US-3983253-A | Ethynylindenyl compounds and derivatives thereof used in the treatment of pain, fever and inflammation | WILLIAM H. RORER, INC. (US) | 1976-09-28 | — | — | US | disclosed |