Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.53 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.53 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.53 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1177476 | 0.99 | HRH3 (0.61) | HRH3EPHX2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1177142 | 0.89 | EPHX2 (0.72) | HRH3EPHX2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL13636466 | 0.85 | SLC6A7 (0.56) | HRH3MAPK10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1177119 | 0.84 | SLC6A7 (0.55) | HRH3MAPK10MEN1KMT2A | |
| SCHEMBL1177319 | 0.82 | PRKAB2 (0.57) | EPHX2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL3275355 | 0.80 | NAMPT (0.60) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL1177305 | 0.76 | ALDH1A1 (0.56) | HRH3MEN1HPGDKMT2A | |
| SCHEMBL4388880 | 0.76 | HRH3 (1.00) | HRH3CNR1 | |
| SCHEMBL1177089 | 0.76 | SLC6A7 (0.55) | HRH3MAPK10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4383019 | 0.75 | HRH3 (1.00) | HRH3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558595-B1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-25 | — | — | EP | disclosed |
| US-7414047-B2 | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-19 | — | — | US | disclosed |
| US-7414047-B2 | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-19 | — | — | US | disclosed |
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | APODACA RICHARD L | 2008-03-06 | — | — | US | disclosed |
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | APODACA RICHARD L | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | HRH2, HNMT, HRH3 | HRH3 3/4885EPHX2 1050/4885PRKAB2 2137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.