Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12330056 | 0.89 | GLA (0.46) | GLAL3MBTL1PSEN1PSEN2APH1B | |
| SCHEMBL23297778 | 0.89 | SMN1; SMN2 (0.51) | GLAL3MBTL1PSEN1PSEN2APH1B | |
| SCHEMBL10017634 | 0.88 | CNR2 (0.54) | GLAL3MBTL1PSEN1PSEN2APH1B | |
| SCHEMBL21595413 | 0.86 | GLA (0.51) | GLAL3MBTL1PSEN1PSEN2APH1B | |
| SCHEMBL13970193 | 0.85 | CNR2 (0.46) | GLAL3MBTL1PSEN1PSEN2APH1B | |
| SCHEMBL2954258 | 0.84 | CA12 (0.71) | GLAL3MBTL1PSEN1PSEN2APH1B | |
| SCHEMBL29199474 | 0.83 | GLA (0.48) | GLAL3MBTL1PSEN1PSEN2APH1B | |
| SCHEMBL10692733 | 0.81 | GLA (0.59) | GLAL3MBTL1CA12CA9KEAP1 | |
| SCHEMBL7961836 | 0.80 | KEAP1 (0.68) | GLAL3MBTL1KEAP1NFE2L2TAS2R14 | |
| SCHEMBL29199488 | 0.80 | GLA (0.45) | GLAL3MBTL1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11192911-B2 | Process for producing ruthenium complexes and intermediates thereof and their use in olefin metathesis | APEIRON SYNTHESIS S.A. (PL) | 2021-12-07 | — | — | US | disclosed |
| EP-3356379-B1 | PROCESS FOR PRODUCING RUTHENIUM COMPLEXES AND INTERMEDIATES THEREOF AND THEIR USE IN OLEFIN METATHESIS | APEIRON SYNTHESIS SA (PL) | 2021-03-10 | — | — | EP | disclosed |
| US-20180065914-A1 | RUTHENIUM POLYMERISATION CATALYSTS | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2018-03-08 | — | — | US | disclosed |
| US-9815765-B2 | Ruthenium polymerisation catalysts | UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) | 2017-11-14 | — | — | US | disclosed |
| US-9815765-B2 | Ruthenium polymerisation catalysts | UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) | 2017-11-14 | — | — | US | disclosed |
| WO-2017185324-A1 | GROUP 8 TRANSITION METAL CATALYSTS AND METHOD FOR MAKING SAME AND PROCESS FOR USE OF SAME IN OLEFIN DISPROPORTIONATION REACTIONS | XIA, LING (CN) | 2017-11-02 | — | — | WO | disclosed |
| EP-2260047-B2 | METHOD FOR MANUFACTURING RUTHENIUM CARBENE COMPLEXES | EVONIK DEGUSSA GMBH (DE) | 2016-07-20 | — | — | EP | disclosed |
| US-9233994-B2 | Ruthenium complexes for use in olefin metathesis | UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) | 2016-01-12 | — | — | US | disclosed |
| US-9233994-B2 | Ruthenium complexes for use in olefin metathesis | UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) | 2016-01-12 | — | — | US | disclosed |
| US-9221042-B2 | Metal complexes, especially the ruthenium complexes, and use thereof | APEIRON SYNTHESIS S.A. (PL) | 2015-12-29 | — | — | US | disclosed |
| US-20120123133-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120123133-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2011117571-A1 | RUTHENIUM COMPLEXES FOR USE IN OLEFIN METATHESIS | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2011-09-29 | — | — | WO | disclosed |
| US-8008224-B2 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | MATERIA, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008224-B2 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | MATERIA, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20110040099-A1 | METHOD FOR MANUFACTURING RUTHENIUM CARBENE COMPLEXES | EVONIK DEGUSSA GMBH (DE) | 2011-02-17 | — | — | US | disclosed |
| US-20110040099-A1 | METHOD FOR MANUFACTURING RUTHENIUM CARBENE COMPLEXES | EVONIK DEGUSSA GMBH (DE) | 2011-02-17 | — | — | US | disclosed |
| US-20070282148-A1 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2007-12-06 | — | — | US | disclosed |
| US-20070282148-A1 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2007-12-06 | — | — | US | disclosed |
| WO-2007075427-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | MATERIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120123133-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | ORC3, OXER1, CBR3 | GLA 4839/4885L3MBTL1 2495/4885PSEN1 4287/4885 |
| US-20110040099-A1 | METHOD FOR MANUFACTURING RUTHENIUM CARBENE COMPLEXES | RNF168, CROCC, MRPL21 | GLA 3586/4885L3MBTL1 3904/4885PSEN1 3562/4885 |
| US-11192911-B2 | Process for producing ruthenium complexes and intermediates thereof and their use in olefin metathesis | POR, CYP1B1, CYP4F11 | GLA 4006/4885L3MBTL1 3997/4885PSEN1 3229/4885 |
| US-20070282148-A1 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | ORC3, OXER1, CBR3 | GLA 4839/4885L3MBTL1 2495/4885PSEN1 4287/4885 |
| US-20180065914-A1 | RUTHENIUM POLYMERISATION CATALYSTS | RRP12, PCBP1, PARG | GLA 4760/4885L3MBTL1 3905/4885PSEN1 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.