Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098702 | 0.85 | TRPM8 (0.68) | TRPM8 | |
| SCHEMBL1107186 | 0.79 | TRPM8 (0.60) | TRPM8 | |
| SCHEMBL1098757 | 0.72 | TRPM8 (0.67) | TRPM8 | |
| SCHEMBL13304444 | 0.71 | TRPM8 (0.51) | TRPM8 | |
| SCHEMBL1099136 | 0.71 | TRPM8 (0.70) | TRPM8 | |
| SCHEMBL13304446 | 0.71 | TRPM8 (0.51) | TRPM8 | |
| SCHEMBL1099135 | 0.70 | TRPM8 (0.71) | TRPM8 | |
| SCHEMBL1099808 | 0.70 | TRPM8 (0.69) | TRPM8 | |
| SCHEMBL1100564 | 0.70 | TRPM8 (0.68) | TRPM8 | |
| SCHEMBL1099087 | 0.70 | TRPM8 (0.70) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153682-B2 | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-04-10 | — | — | US | disclosed |
| US-20090264474-A1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264474-A1 | SULFONAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | TRPM8 1/4885PTGS1 308/4885PTGS2 382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.