Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11771900 | 0.98 | HTT (0.41) | LMNAHTTHIF1ACYP2D6CHRNB4 | |
| SCHEMBL3686301 | 0.98 | LMNA (0.44) | LMNAHTTHIF1ACYP2D6CHRNB4 | |
| SCHEMBL8056836 | 0.95 | HTT (0.42) | LMNAHTTHIF1ACYP2D6CALM1 | |
| SCHEMBL8965651 | 0.95 | HTT (0.42) | LMNAHTTHIF1ACYP2D6CALM1 | |
| SCHEMBL1017459 | 0.87 | HIF1A (0.46) | HIF1ACYP2D6CHRNB4CHRNA3CALM1 | |
| SCHEMBL1964501 | 0.85 | CHRNA7 (0.44) | LMNAHTTHIF1ACYP2D6CHRNB4 | |
| SCHEMBL2063309 | 0.85 | TSHR (0.41) | LMNAHTTHIF1ACYP2D6CALM1 | |
| SCHEMBL14587060 | 0.84 | LMNA (0.46) | LMNAHTTHIF1ACYP2D6POLB | |
| SCHEMBL14508526 | 0.83 | SMN1; SMN2 (0.39) | LMNAHTTHIF1ACYP2D6POLB | |
| SCHEMBL8965143 | 0.83 | CHRNA7 (0.43) | LMNAHTTHIF1ACYP2D6CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3945794-A | Production of level dyeings on acrylonitrile polymer fibers with basic dyes | BASF AKTIENGESELLSCHAFT (DT) | 1976-03-23 | — | — | US | disclosed |