Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.49 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.44 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.43 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.49 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.44 |
| ▸ | CHRNG | P07510 | 2/20 | 0.44 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | CHRND | Q07001 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1177615 | 0.91 | OPRK1 (0.52) | OPRK1SLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL1177377 | 0.89 | SLC6A3 (0.56) | OPRK1SLC6A2SLC6A3SLC6A4CHRNA1 | |
| SCHEMBL1177378 | 0.89 | SLC6A3 (0.56) | OPRK1SLC6A2SLC6A3SLC6A4CHRNA1 | |
| Fumaric Acid SCHEMBL1177491 | 0.85 | OPRK1 (0.49) | OPRK1SLC6A2SLC6A3CHRNA3CYP2D6 | |
| Fumaric Acid SCHEMBL1177545 | 0.84 | OPRK1 (0.47) | OPRK1SLC6A2SLC6A3CYP2D6CYP1A2 | |
| Fumaric Acid SCHEMBL1178501 | 0.83 | SLC6A2 (0.60) | OPRK1SLC6A2SLC6A3CYP2D6CYP1A2 | |
| Fumaric Acid SCHEMBL1177811 | 0.82 | OPRK1 (0.49) | OPRK1SLC6A2SLC6A3 | |
| Fumaric Acid SCHEMBL1178273 | 0.81 | OPRK1 (0.52) | OPRK1SLC6A2SLC6A3CYP2D6 | |
| Fumaric Acid SCHEMBL1178130 | 0.80 | SLC6A2 (0.60) | OPRK1SLC6A2SLC6A3SLC6A4HTR3E | |
| Fumaric Acid SCHEMBL1177672 | 0.79 | OPRK1 (0.50) | OPRK1SLC6A2SLC6A3HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112139-A1 | NOVEL 8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | PETERS DAN | 2011-05-12 | — | — | US | disclosed |
| US-7888358-B2 | Serotonine, dopamine and norendrenaline receptors; antidepressants, anxiolytic agents, eating disorders; obesity; bipolar; drug abuse; neurodegenerative diseases | NEUROSEARCH A/S (DK) | 2011-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112139-A1 | NOVEL 8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | SLC18A2, SLC18A3, SLC6A2 | SLC6A2 3/4885SLC6A4 7/4885MEN1 2969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.