SCHEMBL11776540

SCHEMBL11776540

COC(=O)C(C(=O)C=Cc1cccc(OC)c1)C(=O)OC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.58
FOS P01100 1/20 0.58
JUN P05412 1/20 0.58
BCHE P06276 1/20 0.58
MMP2 P08253 3/20 0.58
MMP9 P14780 3/20 0.58
MMP13 P45452 2/20 0.58
MMP8 P22894 1/20 0.58
ABCG2 Q9UNQ0 3/20 0.54
CYP1A2 P05177 3/20 0.54
CYP2D6 P10635 3/20 0.54
MAOA P21397 2/20 0.54
CYP1A1 P04798 2/20 0.54
CYP1B1 Q16678 2/20 0.54
NR1H4 Q96RI1 3/20 0.53
NPC1 O15118 1/20 0.53
LMNA P02545 1/20 0.53
MAPT P10636 1/20 0.53
HPGD P15428 1/20 0.53
NFKB1 P19838 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11776532 1.00 MAOB (0.58) MAOBFOSJUNBCHEMMP2
SCHEMBL2622487 0.84 MAOB (0.62) MAOBFOSJUNBCHEABCG2
SCHEMBL2123091 0.82 MMP2 (0.70) MAOBMMP2MMP9MMP13MMP8
SCHEMBL30970401 0.80 MAOB (0.66) MAOBFOSJUNBCHEMMP2
SCHEMBL29455174 0.80 MAOB (0.66) MAOBFOSJUNBCHEABCG2
SCHEMBL31737429 0.80 MAOB (0.66) MAOBFOSJUNBCHEMMP2
SCHEMBL3290633 0.80 MAOB (0.66) MAOBFOSJUNBCHEMMP2
SCHEMBL16588978 0.80 MAOB (0.66) MAOBFOSJUNBCHEABCG2
SCHEMBL3290630 0.80 MAOB (0.66) MAOBFOSJUNBCHEMMP2
SCHEMBL3580362 0.80 FOS (0.79) MAOBFOSJUNBCHEABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3946028-A HYPOTENSIVE AGENTS, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-03-23 US disclosed
US-3946027-A HYPOTENSIVE AGENTS, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-03-23 US disclosed
US-3943140-A HYPOTENSIVE, VASODILATION BAYER AKTIENGESELLSCHAFT (DT) 1976-03-09 US disclosed