SCHEMBL11786237

SCHEMBL11786237

C=CCOC(=O)Cc1cn[nH]c1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 1/20 0.46
CYP3A4 P08684 1/20 0.38
NPSR1 Q6W5P4 1/20 0.37
PKM P14618 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TSHR P16473 2/20 0.36
ALDH1A1 P00352 3/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HSD17B10 Q99714 2/20 0.33
KDM4E B2RXH2 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
SNCA P37840 1/20 0.33
NAMPT P43490 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4394864 0.78 NOS2 (0.54) NOS2PKMSMN1; SMN2HSD17B10TDP1
SCHEMBL30672678 0.78 NOS2 (0.53) NOS2NAMPT
SCHEMBL17386357 0.77 CYP3A4 (0.50) CYP3A4NPSR1PKMSMN1; SMN2TSHR
SCHEMBL5687587 0.75 CA2 (0.47) CYP3A4NPSR1PKMSMN1; SMN2ALDH1A1
SCHEMBL7064034 0.73 CYP19A1 (0.54) CYP3A4NPSR1PKMSMN1; SMN2ALDH1A1
SCHEMBL4566407 0.73 SNCA (0.48) CYP3A4TSHRALDH1A1HSD17B10KDM4E
SCHEMBL29620611 0.73 CYP3A4 (0.46) CYP3A4NPSR1PKMSMN1; SMN2TSHR
Hydrochloric Acid SCHEMBL31517445 0.73 NOS2 (0.56) NOS2SMN1; SMN2TSHRALDH1A1HSD17B10
SCHEMBL203679 0.73 ALDH1A1 (0.61) CYP3A4NPSR1PKMSMN1; SMN2TSHR
SCHEMBL9280186 0.72 NAPRT (0.54) CYP3A4NPSR1KDM4ETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4042702-A ANALGESIC, ANTIPYRETIC, ANTIPHLOGISTIC BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DT) 1977-08-16 US disclosed
US-3974176-A ANALGESIC, ANTIPYRETIC, ANTIPHLOGISTIC BYK-GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DT) 1976-08-10 US disclosed