SCHEMBL1179339

SCHEMBL1179339

O=c1nnc2ccccc2c2ccccc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 3/20 0.67
LCK P06239 1/20 0.41
MAP2K3 P46734 1/20 0.41
MAP2K6 P52564 1/20 0.41
BTK Q06187 1/20 0.41
MAP3K19 Q56UN5 1/20 0.41
NEK10 Q6ZWH5 1/20 0.41
ALDH1A1 P00352 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C19 P33261 2/20 0.40
PLAUR Q03405 1/20 0.38
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
PDPK1 O15530 1/20 0.38
CA12 O43570 1/20 0.38
PARP1 P09874 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphoric Acid SCHEMBL4846299 0.90 GPR3 (0.54) GPR3LCKMAP2K3MAP2K6BTK
Benzonaphthyridine SCHEMBL29600756 0.82 GPR3 (1.00) GPR3LCKMAP2K3MAP2K6BTK
Benzonaphthyridine SCHEMBL51197 0.82 GPR3 (1.00) GPR3LCKMAP2K3MAP2K6BTK
Benzonaphthyridine SCHEMBL30897319 0.82 GPR3 (1.00) GPR3LCKMAP2K3MAP2K6BTK
SCHEMBL4485428 0.76 GPR3 (0.87) GPR3LCKMAP2K3MAP2K6BTK
SCHEMBL3630295 0.74 ALDH1A1 (0.43) GPR3LCKMAP2K3MAP2K6BTK
Benzonaphthyridine SCHEMBL38660425 0.68 GPR3 (0.70) GPR3LCKMAP2K3MAP2K6BTK
SCHEMBL7013453 0.68 GPR3 (0.54) GPR3LCKMAP2K3MAP2K6BTK
SCHEMBL11517561 0.68 GPR3 (0.61) GPR3ALDH1A1SMN1; SMN2KMT2AMEN1
SCHEMBL38660517 0.68 GPR3 (0.61) GPR3ALDH1A1SMN1; SMN2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 189 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2796112-B2 Degradable implantable medical devices ELIXIR MEDICAL CORP (US) 2023-08-09 EP claimed
EP-3700534-A1 METHODS OF TREATING PHELAN MCDERMID SYNDROME USING FARNESYL DIBENZODIAZEPINONES Amo Pharma Ltd. (GB) 2020-09-02 EP claimed
US-9974795-B2 Anticancer agent composition CARNA BIOSCIENCES, INC. (JP) 2018-05-22 US claimed
US-20170065609-A1 ANTICANCER AGENT COMPOSITION CARNA BIOSCIENCES, INC. (JP) 2017-03-09 US claimed
EP-3100742-A1 ANTICANCER AGENT COMPOSITION Carna Biosciences Inc. (JP) 2016-12-07 EP claimed
EP-2796112-B1 Degradable implantable medical devices ELIXIR MEDICAL CORP (US) 2016-11-16 EP claimed
US-20100143332-A1 COMBINATION THERAPY FOR PROLIFERATIVE DISORDERS SCHERING CORPORATION 2010-06-10 US claimed
EP-2086644-A2 COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS SCHERING CORPORATION (US) 2009-08-12 EP claimed
US-20090062255-A1 TUMOR-TARGETING EVALUATION METHODOLOGY AND COMPOUNDS RELATED THERETO THALLION PHARMACEUTICALS INC. (CA) 2009-03-05 US claimed
WO-2008063558-A2 COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS SCHERING CORPORATION (US) 2008-05-29 WO claimed
WO-2007102936-A2 POLYNUCLEOTIDES FOR PRODUCTION OF FARNESYL DIBENZODIAZEPINONES THALLION PHARMACEUTICALS INC. (CA) 2007-09-13 WO claimed
EP-0086980-B1 SUBSTITUTED DIBENZODIAZEPINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS Dr. Karl Thomae GmbH (DE) 1986-01-02 EP claimed
EP-0085892-B1 SUBSTITUTED BENZODIAZEPINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM Dr. Karl Thomae GmbH (DE) 1985-12-18 EP claimed
EP-0086980-A1 Substituted dibenzodiazepinones, process for their preparation and medicines containing these compounds Dr. Karl Thomae GmbH (DE) 1983-08-31 EP claimed
EP-0085892-A1 Substituted benzodiazepinones, process for their preparation and medicines containing them Dr. Karl Thomae GmbH (DE) 1983-08-17 EP claimed
US-12600703-B2 Methods of synthesizing farnesyl dibenzodiazepinones AMO PHARMA LTD. (GB) 2026-04-14 US disclosed
EP-4698387-A1 COMPOUND, RUBBER BLEND CONTAINING THE COMPOUND, VEHICLE TYRE COMPRISING THE RUBBER BLEND IN AT LEAST ONE COMPONENT, METHOD FOR PRODUCING THE COMPOUND, AND USE OF THE COMPOUND AS AN ANTI-AGING MEANS AND/OR ANTIOXIDANT AND/OR DYE Continental Reifen Deutschland GmbH (DE) 2026-02-25 EP disclosed
EP-0085892-A1 Substituted benzodiazepinones, process for their preparation and medicines containing them Dr. Karl Thomae GmbH (DE) 1983-08-17 EP disclosed
EP-0085892-A1 Substituted benzodiazepinones, process for their preparation and medicines containing them Dr. Karl Thomae GmbH (DE) 1983-08-17 EP disclosed
EP-0085892-A1 Substituted benzodiazepinones, process for their preparation and medicines containing them Dr. Karl Thomae GmbH (DE) 1983-08-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090062255-A1 TUMOR-TARGETING EVALUATION METHODOLOGY AND COMPOUNDS RELATED THERETO TSPO, MAPK1, MAPK3 GPR3 338/4885LCK 775/4885MAP2K3 114/4885
US-20170065609-A1 ANTICANCER AGENT COMPOSITION CDC7, CDC16, MCM7 GPR3 4218/4885LCK 3016/4885MAP2K3 3136/4885
US-12600703-B2 Methods of synthesizing farnesyl dibenzodiazepinones NR1H2, NR1H3, NR1H4 GPR3 300/4885LCK 4674/4885MAP2K3 1361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.