Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.32 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | GPR6 | P46095 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179379 | 1.00 | EGLN2 (0.34) | EGLN2EGLN1EGLN3PTGDR2KDM4D | |
| SCHEMBL1178262 | 0.91 | GPR6 (0.35) | PTGDR2KDM4DRORCGUCY1A1GUCY1B1 | |
| SCHEMBL1178260 | 0.91 | GPR6 (0.35) | PTGDR2KDM4DRORCGUCY1A1GUCY1B1 | |
| SCHEMBL1178481 | 0.89 | DRD2 (0.35) | PTGDR2KDM4DRORCHTR3AXIAP | |
| SCHEMBL1178476 | 0.89 | DRD2 (0.35) | PTGDR2KDM4DRORCHTR3AXIAP | |
| SCHEMBL1178358 | 0.87 | PTGDR2 (0.37) | PTGDR2KDM4DRORCHTR3AKCNK3 | |
| SCHEMBL1178357 | 0.87 | PTGDR2 (0.37) | PTGDR2KDM4DRORCHTR3AKCNK3 | |
| SCHEMBL1178508 | 0.86 | ADORA2A (0.39) | PTGDR2XIAPGPR6 | |
| SCHEMBL1178506 | 0.86 | ADORA2A (0.39) | PTGDR2XIAPGPR6 | |
| SCHEMBL2029678 | 0.84 | HRH1 (0.34) | PTGDR2RORCHTR3AXIAPSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039855-A1 | Tetrahydrocyclopenta[b]indole Androgen Receptor Modulators | ELI LILLY AND COMPANY (US) | 2011-02-17 | — | — | US | claimed |
| US-8486943-B2 | Tetrahydrocyclopenta[b]indole androgen receptor modulators | ELI LILLY AND COMPANY (US) | 2013-07-16 | — | — | US | disclosed |
| EP-2297100-B1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | LILLY CO ELI (US) | 2012-10-31 | — | — | EP | disclosed |
| US-20110039855-A1 | Tetrahydrocyclopenta[b]indole Androgen Receptor Modulators | ELI LILLY AND COMPANY (US) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039855-A1 | Tetrahydrocyclopenta[b]indole Androgen Receptor Modulators | AR, ADRA1B, ADRB1 | EGLN2 3434/4885EGLN1 3043/4885EGLN3 3833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.