Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 14/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833920 | 0.78 | PGR (0.42) | PGRHTR2AHTR2C | |
| SCHEMBL948578 | 0.78 | PGR (0.69) | PGRMAPTTP53CYP1A2CYP2C9 | |
| SCHEMBL24112733 | 0.78 | PGR (0.69) | PGRMAPTTP53CYP1A2CYP2C9 | |
| SCHEMBL11366496 | 0.75 | MAOA (0.44) | CHRM1MAPTTP53HTR2AHTR2C | |
| SCHEMBL11526416 | 0.74 | CHRM1 (0.43) | CHRM1MAPTHTR2AHTR2CHTR2B | |
| SCHEMBL5873718 | 0.72 | EGFR (0.47) | CHRM1 | |
| SCHEMBL10969953 | 0.71 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL21284261 | 0.70 | CHRM1 (0.46) | CHRM1 | |
| SCHEMBL11657761 | 0.69 | CHRM1 (0.42) | CHRM1HTR2AHTR2CHTR2BADRB1 | |
| SCHEMBL12693588 | 0.69 | PGR (0.44) | PGRMAPTTP53CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242934-B2 | Process for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses | BAYER CROPSCIENCE AG (DE) | 2016-01-26 | — | — | US | disclosed |
| EP-2424835-B1 | METHOD FOR PRODUCING OXINDOLES AND ORTHO-SUBSTITUTED ANILINES | BAYER IP GMBH (DE) | 2015-07-01 | — | — | EP | disclosed |
| CN-102459163-B | Process for the preparation of oxindoles and ortho-substituted anilines and their use as synthesis intermediates | BAYER CROPSCIENCE AG | 2015-05-13 | — | — | CN | disclosed |
| US-20130281711-A1 | PROCESS FOR THE PREPARATION OF OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THEIR USE AS INTERMEDIATES FOR SYNTHESES | BAYER CROPSCIENCE AG (DE) | 2013-10-24 | — | — | US | disclosed |
| US-8492590-B2 | Process for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses | BAYER CROPSCIENCE AG (DE) | 2013-07-23 | — | — | US | disclosed |
| WO-2012028162-A1 | PROCESS FOR PREPARING OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THE USE THEREOF AS INTERMEDIATES FOR SYNTHESES | BAYER CROPSCIENCE AG (DE) | 2012-03-08 | — | — | WO | disclosed |
| EP-2424835-A1 | METHOD FOR PRODUCING OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THE USE THEREOF AS INTERMEDIATE PRODUCTS FOR SYNTHESES | Bayer CropScience AG (DE) | 2012-03-07 | — | — | EP | disclosed |
| US-20110118478-A1 | PROCESS FOR THE PREPARATION OF OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THEIR USE AS INTERMEDIATES FOR SYNTHESES | BAYER CROPSCIENCE AG (DE) | 2011-05-19 | — | — | US | disclosed |
| WO-2010127786-A1 | METHOD FOR PRODUCING OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THE USE THEREOF AS INTERMEDIATE PRODUCTS FOR SYNTHESES | BAYER CROPSCIENCE AG (DE) | 2010-11-11 | — | — | WO | disclosed |
| EP-2246326-A1 | Method for producing oxindoles and ortho-substituted anilines and their use as intermediate products for syntheses | Bayer CropScience AG (DE) | 2010-11-03 | — | — | EP | disclosed |
| US-4252723-A | Air oxidation of oxindoles to isatins | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1981-02-24 | — | — | US | disclosed |
| US-4188325-A | Isatin process and products | REGENTS OF UNIVERSITY OF MINNESOTA (US) | 1980-02-12 | — | — | US | disclosed |
| US-4186132-A | Isatin products | THE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1980-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118478-A1 | PROCESS FOR THE PREPARATION OF OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THEIR USE AS INTERMEDIATES FOR SYNTHESES | TH, OXSR1, AOX1 | CHRM1 282/4885PGR 3083/4885MAPT 1762/4885 |
| US-20130281711-A1 | PROCESS FOR THE PREPARATION OF OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THEIR USE AS INTERMEDIATES FOR SYNTHESES | TH, OXSR1, AOX1 | CHRM1 282/4885PGR 3083/4885MAPT 1762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.