Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11838989 | 0.84 | MEN1 (0.39) | TNFNOD2NOD1APPTSHR | |
| SCHEMBL11802842 | 0.78 | CISD1 (0.47) | APPCISD1 | |
| SCHEMBL11788087 | 0.78 | CISD1 (0.53) | TSHRLMNACISD1 | |
| SCHEMBL11780949 | 0.78 | CISD1 (0.46) | BRAFCISD1 | |
| SCHEMBL11844344 | 0.77 | CISD1 (0.41) | APPMEN1KMT2ACISD1 | |
| SCHEMBL11777207 | 0.75 | SIRT2 (0.39) | BRAFAPPTSHRLMNAMEN1 | |
| Acetanilide SCHEMBL11798783 | 0.74 | CISD1 (0.49) | BRAFAPPCISD1 | |
| SCHEMBL11820413 | 0.71 | CISD1 (0.45) | APPTSHRMEN1KMT2ACISD1 | |
| SCHEMBL11823275 | 0.69 | CISD1 (0.57) | APPTSHRMEN1KMT2ACISD1 | |
| SCHEMBL22836882 | 0.69 | AKR1C3 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3992440-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1976-11-16 | — | — | US | disclosed |
| US-3982018-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1976-09-21 | — | — | US | disclosed |
| US-3939267-A | DIURETIC | CIBA-GEIGY CORPORATION (US) | 1976-02-17 | — | — | US | disclosed |