Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11793999 | 0.90 | ALDH1A1 (0.41) | HTTSMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL11791998 | 0.89 | KMT2A (0.53) | SMN1; SMN2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL11788809 | 0.86 | ALDH1A1 (0.37) | HTTSMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL11790990 | 0.84 | PTGS1 (0.44) | HTTSMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL11791704 | 0.82 | KDM4E (0.41) | SMN1; SMN2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL11797983 | 0.82 | CHRM5 (0.43) | HTTSMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL11790071 | 0.81 | ALDH1A1 (0.52) | SMN1; SMN2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL11789560 | 0.79 | CYP1A2 (0.45) | SMN1; SMN2TSHRALDH1A1MAPTGAA | |
| SCHEMBL11796546 | 0.78 | KMT2A (0.45) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL11790430 | 0.78 | LMNA (0.40) | SMN1; SMN2LMNAALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3998954-A | 1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflammatory agents | PFIZER INC. (US) | 1976-12-21 | — | — | US | disclosed |