Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Protirelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR known ✓ | P34981 | 6/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Protirelin SCHEMBL14280929 | 1.00 | TRHR (0.71) | TRHR | |
| Protirelin SCHEMBL8364920 | 1.00 | TRHR (0.71) | TRHR | |
| Protirelin SCHEMBL2182035 | 1.00 | TRHR (0.71) | TRHR | |
| Protirelin SCHEMBL20659679 | 1.00 | TRHR (0.71) | TRHR | |
| SCHEMBL11336847 | 0.97 | TRHR (0.68) | TRHR | |
| Protirelin SCHEMBL11669085 | 0.97 | TRHR (0.68) | TRHR | |
| SCHEMBL10589322 | 0.96 | TRHR (0.76) | TRHR | |
| Protirelin SCHEMBL10760265 | 0.95 | TRHR (0.65) | TRHR | |
| SCHEMBL1369554 | 0.94 | TRHR (0.63) | TRHR | |
| SCHEMBL9474691 | 0.92 | TRHR (0.61) | TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3988307-A | ATTACHING AN ALPHA,BETA-UNSATURATED AMINO ACID TO A SOLID SUPPORT; ACIDIC AQUEOUS RELEASE AGENT | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1976-10-26 | — | — | US | disclosed |