SCHEMBL11799765

SCHEMBL11799765

Clc1cc(CCBr)ccc1C1CCCCC1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NUDT1 P36639 1/20 0.44
BACE1 P56817 1/20 0.44
SIGMAR1 Q99720 9/20 0.40
TMEM97 Q5BJF2 1/20 0.40
EBP Q15125 1/20 0.40
CEL P19835 2/20 0.38
THRB P10828 1/20 0.36
CSNK2A1 P68400 2/20 0.35
PTGDR Q13258 2/20 0.34
PTGDR2 Q9Y5Y4 2/20 0.34
PTGER2 P43116 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11675755 0.85 NUDT1 (0.45) NUDT1BACE1SIGMAR1TMEM97EBP
SCHEMBL27520139 0.84 NUDT1 (0.44) NUDT1BACE1SIGMAR1TMEM97EBP
SCHEMBL11674401 0.84 BACE1 (0.48) NUDT1BACE1SIGMAR1TMEM97EBP
SCHEMBL11674174 0.81 SIGMAR1 (0.43) NUDT1BACE1SIGMAR1TMEM97EBP
SCHEMBL8330793 0.81 NUDT1 (0.52) NUDT1BACE1SIGMAR1TMEM97EBP
SCHEMBL11675518 0.80 MEN1 (0.46) NUDT1BACE1SIGMAR1TMEM97EBP
SCHEMBL10829892 0.80 SIGMAR1 (0.48) NUDT1BACE1SIGMAR1TMEM97EBP
SCHEMBL3900326 0.80 NUDT1 (0.43) NUDT1BACE1SIGMAR1TMEM97EBP
SCHEMBL11673726 0.79 NUDT1 (0.43) NUDT1BACE1SIGMAR1TMEM97EBP
SCHEMBL11674093 0.79 PTGDR2 (0.49) NUDT1BACE1THRBPTGDRPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3950427-A ANTIINFLAMMATORY, ANTIPYRETIC BOEHRINGER INGELHEIM GMBH (DT) 1976-04-13 US disclosed