SCHEMBL11800413

SCHEMBL11800413

CCOC(=O)C1=C(N)NC(C)=CC1c1cccc(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1D Q01668 6/20 0.51
CACNA1F O60840 1/20 0.51
CACNA1S Q13698 1/20 0.51
CACNA1C Q13936 1/20 0.51
ABCC1 P33527 1/20 0.46
ACHE P22303 1/20 0.45
CACNA1B Q00975 8/20 0.44
BCHE P06276 1/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
HPGD P15428 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42
HIF1A Q16665 1/20 0.42
HSD17B10 Q99714 1/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11800038 0.86 CACNA1D (0.62) CACNA1DCACNA1FCACNA1SCACNA1CCACNA1B
SCHEMBL11799255 0.85 CACNA1D (0.60) CACNA1DKDM4EALDH1A1
SCHEMBL11526085 0.81 ABCC1 (0.61) CACNA1DCACNA1FCACNA1SCACNA1CABCC1
SCHEMBL11007804 0.80 TSHR (0.54) CACNA1DCACNA1FCACNA1SCACNA1CABCC1
SCHEMBL3026966 0.78 ABCC1 (0.71) CACNA1DCACNA1FCACNA1SCACNA1CABCC1
SCHEMBL11806148 0.77 ALDH1A1 (0.61) CACNA1DABCC1ACHEBCHEKDM4E
SCHEMBL11773488 0.77 CACNA1F (0.56) CACNA1DCACNA1FCACNA1SCACNA1CABCC1
SCHEMBL11006596 0.76 CACNA1D (0.48) CACNA1DCACNA1FCACNA1SCACNA1CCACNA1B
SCHEMBL11803207 0.76 CA1 (0.50) CACNA1DCACNA1FCACNA1SCACNA1CKDM4E
SCHEMBL11524110 0.76 CACNA1B (0.57) CACNA1DCACNA1FCACNA1SCACNA1CABCC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3989708-A HYPOTENSIVE, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-11-02 US disclosed
US-3989708-A HYPOTENSIVE, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-11-02 US disclosed
US-3862162-A CERTAIN-2-AMINO-1,4-DIHYDRO-4-PHENYL-6-LOWER ALKYL (OR PHENYL)-3-PYRIDINECARBOXYLATES BAYER AG 1975-01-21 US disclosed