Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118073 | 0.76 | PIK3CA (0.49) | PIK3CAMTOR | |
| SCHEMBL114801 | 0.73 | PIK3CA (0.54) | PIK3CAMTOR | |
| SCHEMBL115669 | 0.71 | SIGMAR1 (0.43) | SIGMAR1AVPR1BLRRK2NPC1 | |
| SCHEMBL166145 | 0.69 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL113876 | 0.64 | SIGMAR1 (0.53) | SIGMAR1 | |
| SCHEMBL28193623 | 0.63 | SIGMAR1 (0.48) | SIGMAR1LRRK2NPC1SMN1; SMN2ABL1 | |
| SCHEMBL13119693 | 0.62 | KMT2A (0.54) | SMN1; SMN2 | |
| SCHEMBL29339594 | 0.61 | SIGMAR1 (0.45) | PIK3CASIGMAR1ABL1BCRCDK1 | |
| SCHEMBL15906057 | 0.61 | SIGMAR1 (0.49) | SIGMAR1SYKRAB9A | |
| SCHEMBL12752879 | 0.61 | SIGMAR1 (0.49) | SIGMAR1AVPR1BLRRK2SYKCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |