Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | AVPR1B | P47901 | 5/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116160 | 0.86 | MAPT (0.43) | NPC1 | |
| SCHEMBL29955596 | 0.86 | MAPT (0.43) | NPC1 | |
| SCHEMBL15987943 | 0.75 | SIGMAR1 (0.56) | SIGMAR1AVPR1BPOLBSLC6A3 | |
| SCHEMBL113876 | 0.73 | SIGMAR1 (0.53) | SIGMAR1RPS6KA3POLB | |
| SCHEMBL28193623 | 0.71 | SIGMAR1 (0.48) | SIGMAR1RPS6KA3POLBLRRK2NPC1 | |
| SCHEMBL118074 | 0.71 | PIK3CA (0.36) | SIGMAR1AVPR1BLRRK2NPC1 | |
| SCHEMBL12311146 | 0.71 | LPL (0.36) | NPC1 | |
| SCHEMBL29339594 | 0.70 | SIGMAR1 (0.45) | SIGMAR1RPS6KA3POLB | |
| SCHEMBL115750 | 0.69 | MEN1 (0.49) | POLB | |
| SCHEMBL29953762 | 0.69 | MEN1 (0.49) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |