Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115530 | 0.84 | DRD2 (0.56) | DRD2DRD3DRD4HRH3MAPT | |
| SCHEMBL114612 | 0.81 | KCNH2 (0.55) | SIGMAR1KMT2AHRH3KCNH2LTA4H | |
| SCHEMBL2532973 | 0.81 | SIGMAR1 (0.53) | SIGMAR1POLBL3MBTL3HTTKMT2A | |
| SCHEMBL15987551 | 0.81 | SIGMAR1 (0.60) | SIGMAR1POLBL3MBTL3HRH3 | |
| SCHEMBL12752879 | 0.78 | SIGMAR1 (0.49) | SIGMAR1POLBL3MBTL3HTTKMT2A | |
| SCHEMBL115177 | 0.78 | HRH3 (0.40) | SIGMAR1DRD2DRD3DRD4HRH3 | |
| SCHEMBL28251846 | 0.76 | HIF1A (0.48) | SIGMAR1HTTHRH3 | |
| SCHEMBL15806388 | 0.73 | HRH3 (0.76) | SIGMAR1POLBL3MBTL3HTTKMT2A | |
| SCHEMBL29921644 | 0.73 | HRH3 (0.76) | SIGMAR1POLBL3MBTL3HTTKMT2A | |
| SCHEMBL115669 | 0.73 | SIGMAR1 (0.43) | SIGMAR1POLBRPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |