Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1181699 | 1.00 | NOS3 (0.43) | NOS3NOS1NOS2HHATSMN1; SMN2 | |
| SCHEMBL1181974 | 1.00 | NOS3 (0.43) | NOS3NOS1NOS2HHATSMN1; SMN2 | |
| SCHEMBL2994358 | 0.87 | SMN1; SMN2 (0.42) | NOS3NOS1NOS2HHATSMN1; SMN2 | |
| SCHEMBL2994354 | 0.87 | SMN1; SMN2 (0.42) | NOS3NOS1NOS2HHATSMN1; SMN2 | |
| SCHEMBL2994360 | 0.87 | SMN1; SMN2 (0.42) | NOS3NOS1NOS2HHATSMN1; SMN2 | |
| SCHEMBL3004324 | 0.86 | NOS3 (0.42) | NOS3NOS1NOS2HHATSMN1; SMN2 | |
| SCHEMBL3004323 | 0.86 | NOS3 (0.42) | NOS3NOS1NOS2HHATSMN1; SMN2 | |
| SCHEMBL3004325 | 0.86 | NOS3 (0.42) | NOS3NOS1NOS2HHATSMN1; SMN2 | |
| SCHEMBL2992673 | 0.85 | BRD4 (0.43) | NOS3NOS1NOS2HHATSMN1; SMN2 | |
| SCHEMBL2992674 | 0.85 | BRD4 (0.43) | NOS3NOS1NOS2HHATSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981337-B1 | THIOPHENYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ATHERSYS INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-20140206672-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ABT HOLDING COMPANY (US) | 2014-07-24 | — | — | US | disclosed |
| US-8716276-B2 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2C receptor ligands and uses thereof | ATHERSYS, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20110112072-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | TUMEY L NATHAN | 2011-05-12 | — | — | US | disclosed |
| US-7893051-B2 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112072-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | HTR2C, HTR5A, HTR2A | NOS3 1373/4885NOS1 2092/4885NOS2 1114/4885 |
| US-20140206672-A1 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | HTR2C, HTR5A, HTR2A | NOS3 1373/4885NOS1 2092/4885NOS2 1114/4885 |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | HTR2C, HTR5A, HTR2A | NOS3 1373/4885NOS1 2092/4885NOS2 1114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.