Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2994354 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2HSD17B10BRD4PKMNOS3 | |
| SCHEMBL2994360 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2HSD17B10BRD4PKMNOS3 | |
| SCHEMBL1181974 | 0.87 | NOS3 (0.43) | SMN1; SMN2HSD17B10BRD4PKMNOS3 | |
| SCHEMBL1181699 | 0.87 | NOS3 (0.43) | SMN1; SMN2HSD17B10BRD4PKMNOS3 | |
| SCHEMBL1181973 | 0.87 | NOS3 (0.43) | SMN1; SMN2HSD17B10BRD4PKMNOS3 | |
| SCHEMBL3004324 | 0.86 | NOS3 (0.42) | SMN1; SMN2HSD17B10BRD4PKMNOS3 | |
| SCHEMBL3004323 | 0.86 | NOS3 (0.42) | SMN1; SMN2HSD17B10BRD4PKMNOS3 | |
| SCHEMBL3004325 | 0.86 | NOS3 (0.42) | SMN1; SMN2HSD17B10BRD4PKMNOS3 | |
| SCHEMBL2992673 | 0.85 | BRD4 (0.43) | SMN1; SMN2HSD17B10BRD4PKMNOS3 | |
| SCHEMBL2992674 | 0.85 | BRD4 (0.43) | SMN1; SMN2HSD17B10BRD4PKMNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778243-B1 | SUBSTITUTED AZEPINE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | ATHERSYS INC (US) | 2012-10-31 | — | — | EP | disclosed |
| US-20100190772-A1 | Substituted Azepine Derivatives As Serotonin Receptor Modulators | BENNANI YOUSSEF L | 2010-07-29 | — | — | US | disclosed |
| US-7718647-B2 | Substituted azepine derivatives as serotonin receptor modulators | ATHERSYS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-20060003990-A1 | Substituted azepine derivatives as serotonin receptor modulators | ATHERSYS, INC. | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060003990-A1 | Substituted azepine derivatives as serotonin receptor modulators | HTR5A, HTR4, HTR7 | SMN1; SMN2 4252/4885HSD17B10 2187/4885BRD4 977/4885 |
| US-20100190772-A1 | Substituted Azepine Derivatives As Serotonin Receptor Modulators | HTR5A, HTR4, HTR2C | SMN1; SMN2 4290/4885HSD17B10 2094/4885BRD4 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.