Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 12/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11827953 | 0.86 | GABRA1 (0.53) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11827336 | 0.86 | GABRA1 (0.54) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11823283 | 0.83 | OPRK1 (0.46) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11843774 | 0.83 | GABRA5 (0.63) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11732360 | 0.83 | OPRK1 (0.64) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11828627 | 0.81 | CHRM1 (0.48) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11829706 | 0.80 | GABRA5 (0.38) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11829808 | 0.80 | CHRM1 (0.47) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11830963 | 0.80 | GABRA1 (0.59) | GABRA1GABRA5GABRA2GABRA3GABRG2 | |
| SCHEMBL11830483 | 0.80 | GABRA1 (0.58) | GABRA1GABRA5GABRA2GABRA3GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3933794-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS | THE UPJOHN COMPANY (US) | 1976-01-20 | — | — | US | disclosed |