Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11828525 | 0.81 | TDP1 (0.38) | TDP1RAB9AMAPTLMNAGAA | |
| SCHEMBL11822836 | 0.80 | HSD17B10 (0.41) | MAPTGAAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11820141 | 0.78 | KDM4E (0.38) | TDP1RAB9AMAPTLMNAGAA | |
| SCHEMBL11828529 | 0.78 | TDP1 (0.41) | TDP1RAB9AMAPTLMNAGAA | |
| SCHEMBL11822888 | 0.72 | HSD17B10 (0.46) | RAB9AMAPTLMNAGAAKDM4E | |
| SCHEMBL11819039 | 0.72 | TSHR (0.39) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL11823316 | 0.72 | TSHR (0.39) | MAPTLMNAKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11826033 | 0.70 | KDM4E (0.39) | RAB9AMAPTLMNAGAAKDM4E | |
| SCHEMBL11093234 | 0.70 | ALDH1A1 (0.39) | TDP1MAPTLMNAL3MBTL1KDM4E | |
| SCHEMBL11096008 | 0.70 | POLB (0.41) | TDP1RAB9ALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3979444-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, HYPOTENSIVES | THE UPJOHN COMPANY (US) | 1976-09-07 | — | — | US | disclosed |