Balsalazide

Balsalazide

SCHEMBL118300

O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ALOX5PPARGPTGS1PTGS2

The experimentally established mechanism targets of Balsalazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 known ✓ P23219 1/20 0.51
PTGS2 known ✓ P35354 1/20 0.51
SIRT5 Q9NXA8 5/20 1.00
NME4 O00746 3/20 1.00
GCDH Q92947 3/20 1.00
TDP1 Q9NUW8 3/20 1.00
HRH3 Q9Y5N1 2/20 1.00
ADORA3 P0DMS8 1/20 1.00
CHRM1 P11229 1/20 1.00
ADORA2A P29274 1/20 1.00
AVPR2 P30518 1/20 1.00
AGTR1 P30556 1/20 1.00
SLC6A4 P31645 1/20 1.00
AVPR1A P37288 1/20 1.00
HTR3A P46098 1/20 1.00
SLC29A1 Q99808 1/20 1.00
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
BLVRB P30043 2/20 0.59
PDE4A P27815 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Balsalazide SCHEMBL138311 1.00 SIRT5 (1.00) SIRT5NME4GCDHTDP1HRH3
Balsalazide SCHEMBL3267109 1.00 SIRT5 (1.00) SIRT5NME4GCDHTDP1HRH3
Balsalazide SCHEMBL29377041 1.00 SIRT5 (1.00) SIRT5NME4GCDHTDP1HRH3
Balsalazide SCHEMBL7908058 0.99 SIRT5 (0.97) SIRT5NME4GCDHTDP1HRH3
Balsalazide SCHEMBL28818120 0.99 SIRT5 (0.97) SIRT5NME4GCDHTDP1HRH3
Balsalazide SCHEMBL134019 0.99 SIRT5 (0.97) SIRT5NME4GCDHTDP1HRH3
Balsalazide SCHEMBL5598491 0.99 SIRT5 (0.97) SIRT5NME4GCDHTDP1HRH3
Balsalazide SCHEMBL133200 0.97 SIRT5 (0.95) SIRT5NME4GCDHTDP1HRH3
Balsalazide SCHEMBL20184744 0.93 SIRT5 (0.87) SIRT5NME4GCDHTDP1HRH3
Balsalazide SCHEMBL17392780 0.93 SIRT5 (0.87) SIRT5NME4GCDHTDP1HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9137 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260138973-A1 SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE SITRYX THERAPEUTICS LTD (GB) 2026-05-21 US claimed
US-20260137680-A1 NOVEL COMPOUNDS SITRYX THERAPEUTICS LTD (GB) 2026-05-21 US claimed
US-20260085061-A1 PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS SITRYX THERAPEUTICS LIMITED (GB) 2026-03-26 US claimed
EP-4705511-A1 DNA METHYLATION-BASED ALGORITHM TO DIAGNOSE IRRITABLE BOWEL SYNDROME AND OTHER GI CONDITIONS The Regents of the University of California (US) 2026-03-11 EP claimed
EP-4701663-A1 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS, COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-03-04 EP claimed
EP-4687850-A1 ORAL DRUG DOSAGE FORMS FOR COLON DELIVERY AND METHODS OF USE AND MAKING THEREOF Triastek, Inc. (CN) 2026-02-11 EP claimed
EP-4689191-A2 METHODS OF CLASSIFYING AND TREATING INFLAMMATORY BOWEL DISEASE Baylor College of Medicine (US) 2026-02-11 EP claimed
US-20260007611-A1 ULTRASOUND RESPONSIVE NANOCLUSTER FOR CANCER TREATMENT AND METHOD FOR MANUFACTURING THE SAME INDUSTRY UNIV COOPERATION FOUNDATION YEUNGNAM UNIV (KR) 2026-01-08 US claimed
WO-2025245006-A1 EXHALED BREATH OF VOLATILE ORGANIC COMPOUNDS FOR IBD DIAGNOSIS AND MANAGEMENT THE CLEVELAND CLINIC FOUNDATION (US) 2025-11-27 WO claimed
US-12473370-B2 TL1A associated antibody compositions and methods of use Absci Corporation (US) 2025-11-18 US claimed
WO-2000069255-A1 ANTI-INFLAMMATORY THERAPY FOR INFLAMMATORY MEDIATED INFECTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-11-23 WO claimed
WO-2000056772-A1 HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING KNOLL GMBH (DE) 2000-09-28 WO claimed
WO-2000045803-A2 USE OF 5-AMINOSALICYLATES AS ANTIMICROBIAL AGENTS CEDARS-SINAI MEDICAL CENTER (US) 2000-08-10 WO claimed
EP-0980246-A1 THERAPY FOR CONSTIPATION BORODY, Thomas Julius (AU) 2000-02-23 EP claimed
WO-2000004924-A1 COMPOSITION AND PHARMACEUTICAL DOSAGE FORM FOR COLONIC DRUG DELIVERY USING POLYSACCHARIDES SAMYANG CORPORATION (KR) 2000-02-03 WO claimed
EP-0974344-A2 Composition and pharmaceutical dosage form for colonic drug delivery using polysaccharides Samyang Corporation (KR) 2000-01-26 EP claimed
US-5905073-A ANTICARCINOGENIC AGENTS SALIX PHARMACEUTICALS, INC. (US) 1999-05-18 US claimed
WO-1998050043-A1 NOVEL THERAPY FOR CONSTIPATION BORODY THOMAS J (AU) 1998-11-12 WO claimed
CN-1140994-A Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents SALIX PHARMACEUTICALS INC (US) 1997-01-22 CN claimed
US-5498608-A Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents SALIX PHARMACEUTICALS (US) 1996-03-12 US claimed